EDC & eCRF

EDC Configuration in Days, Not Weeks

Trialhelix generates eCRF form structures, visit schedules, and edit check logic from your protocol and DMP — cutting EDC setup from 3–5 weeks to 4–6 days per study.

4–6 days to EDC setup
300+ validated edit checks
~60% query cycle reduction
Feature Detail

How the EDC Module Works

The EDC configuration process starts with your protocol synopsis and Data Management Plan. Trialhelix parses the study objectives, visit schedule, and endpoints to generate an initial eCRF structure — forms, pages, fields, and their data types.

Your CDM team reviews and approves the generated structure before any data collection begins. The review creates an auditable approval record. After approval, edit checks are applied from the rule library — matching your study design's specific data types and ranges.

  • Protocol ingestion in DMP template format or manual specification
  • eCRF form generation: demographics, vitals, AE, concomitant medications, labs, PK sampling
  • Edit check library: range checks, consistency checks, cross-form derivations
  • Visit schedule matrix with form assignment and mandatory/conditional logic
  • CRF completion guidelines auto-populated per field type
  • UAT environment for CDM and investigator sign-off before go-live
Trialhelix EDC interface showing eCRF form configuration and edit check library
Technical Specification

EDC Module Capabilities

Capability Status
Protocol-driven eCRF generation Available
Visit schedule with conditional branching Available
300+ validated edit check library Available
CDISC ODM-XML export of eCRF design Available
Electronic signature workflow (21 CFR Part 11 aligned) Available
Query generation: manual, auto, and SDV Available
Protocol amendment versioning with impact assessment Available
Multi-language eCRF support Available
Offline data entry for low-connectivity sites Roadmap Q3 2026
Workflow Connection

EDC in the Study Timeline

The EDC module connects to every other phase of the study lifecycle — randomization, data management, site monitoring, and reporting all reference the same eCRF structure.

01

Protocol Ingestion

Upload DMP and protocol synopsis. Trialhelix extracts study structure, visit schedule, and endpoint definitions to seed the eCRF configuration.

02

CDM Review & Approval

Your team reviews the generated eCRF structure. Edits are tracked. Approval creates an audit record. UAT environment available for sponsor review.

03

Edit Check Application

Rule library matches checks to your data types. Custom rules can be added by study. All checks generate CDISC-compatible query codes.

04

Study Go-Live

Site training materials are auto-generated from the approved eCRF structure. Investigator accounts are provisioned with role-based access per site.

05

SDTM Mapping in Parallel

CDISC variable mappings begin at study go-live — not at data lock. SDTM domain structures are built alongside data collection and updated with each protocol amendment.

See EDC Configuration on Your Protocol

Bring your protocol synopsis to a 30-minute call and we will walk through how the EDC module would configure your specific study — forms, edit checks, and SDTM mapping.